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This includes age-related memory loss, difficulties with focus and concentration, and mild cognitive impairment

However, the risk of bone fractures may be increased by supplements containing 25 mcg or more daily, according to some research

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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed