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In the short-term clinical trial (4-8 weeks), the patients had good tolerance and no serious adverse reactions were observed

Fungal beta-glucans as adjuvants for treating cancer patients - A systematic review of clinical trials

Clinically, modulating acupoints by acupuncture and moxibustion (also including tuina, cupping [] and guasha []) has been extensively used to treat human diseases by the Chinese for more 2200 years

The accumulation of ROS and RNS results in the oxidation of biological molecules such as DNA, protein, and lipids, which leads to oxidative damage in cells, tissues, or organs (Zhang et al., 2020)