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L.HickmanM.SteelN.JonesP

Grace ND, West DM, Sargison ND

Inspired by this result, Crick showed that insertion or deletion of 1 or 2 bases causes proteins to become non-functional, but 3 base mutants still produce functional protein

Thus, the holoenzyme is catalytically more efficient and less subject to inhibition by GSH than GCLC alone
