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Mitochondrial DNA (mtDNA) and respiratory enzymes lose normal structure and function when nuclear genes encoding the related mitochondrial factors are impaired, resulting in deficiency in energy production

However, in this section of the review, we will attempt to connect some defects observed in low AsA mutants with possible changes in the respiratory pathways

1,3-BPG can form reactive intermediates and react with amino groups, but PARK7 disrupts these intermediates, preventing improper modifications of proteins and metabolites