diethyl maleate glutathione depletion Nuclear trapping of inactive FOXO1 by the Nrf2 activator Stimulation of de novo glutathione
Description
GSH-independence can be conferred by mutations at the protomer interface, consistent with GSH binding to protomers driving the formation of pentameric units critical to assembly 16,17
Trepanier LA, Cribb AE, Spielberg SP, et al
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Once a portion of the original H 2 O 2 substrate has been consumed by GPx, any remaining H 2 O 2 reacts with Fe 2+ ions from the FAS via a Fenton-type redox mechanism, oxidizing Fe 2+ to Fe +
