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In bronchiectasis, an exacerbation episode is characterized by deteriorations in at least three key symptoms within 48 hsuch as increased cough, changes in the sputum volume and/or consistency, increased sputum purulence, worsened breathlessness and/or reduced exercise tolerance, fatigue, malaise, and hemoptysisthat necessitate a change in treatment [28]

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doi: 10.1038/ncomms13997 20 WongSWKwonMJChoiAMKKimHPNakahiraKHwangDH