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Interestingly, loss of FH also triggered a compensatory rise in GSH levels by upregulation of cystine transport SLC7A11 expression and increases in cystine uptake and glutaminolysis-dependent GSH biosynthesis (121)
Glutathione S-transferase an enzyme involved in animal cell detoxication is one of the most widely used tags in molecular biology
In summary, endocrinologists need to be aware of the severe metabolic and liver-specific complications of NASH and establish early-on a long-term management plan
10.1016/j.intimp.2020.106607
