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Journal of the Chemical Society, Chemical Communications, (21), 1111-1114

One study compared in vivo levels of GSH in the motor cortex of 11 ALS patients with those in 11 age-matched healthy volunteers and determined that GSH levels were 31% lower in ALS patients than in healthy volunteers (Weiduschat et al., 2014)

Additionally, NAC treatment was found to significantly improve glutathione S-transferase (GST) activity, as well as decrease nitric oxide and MDA concentrations in plasma on day 3 and day 5 following initiation of treatment compared to the group that only received supportive treatment

Conjugation of brain-targeting peptide is also proved to be an effective method to improve the brain accumulation