glutathione and brain cancer Tumor-targeted oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma Glutathione in Cancer Cell Death

Adaptation of a membrane-active peptide to heterogeneous environment

M.RasanenJ.TikkanenH.SormunenR.MakikallioK.KivirikkoK

Fe-doped and doxorubicin loaded HA@Cu 2-X S-PEG (PHCN) nanomaterials were designed as targeted Fe-PHCN@DOX nano-reactors to maximize the effect of ICD to promote antigen presentation thereby stimulating T cell activation, in addition, Fe-PHCN@DOX can reprogram M2 TAMs into M1 TAMs by alleviating tumor hypoxia, at the same time T cell activation is promoted through blockade of the PD-1/PD-L1 immunosuppressive pathway by anti-PD-L1 nanoantibodies thereby achieving effective antitumor effects (226)

Peters, MO, can be a practical tool