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Finally, it would be interesting to observe metabolic changes that occur during the course of treatment, especially treatments that provide factors critical to metabolic functioning (Schaevitz et al., 2012)
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Alterations in NO-mediated endothelium-dependent vasodilation results in widespread vasoconstriction and coagulation abnormalities and is considered to be an early step in the development of atherosclerosis
That can make the category look broader than the biology
