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Although some xenobiotics such as phenobarbital are associated with hepatocellular hypertrophy throughout a long-term administration, the initial hypertrophy associated with other xenobiotics such as safrole and Ponceau is not sustained (Crampton et al
Blankenberg S, Rupprecht HJ, Bickel C, et al
Gianazza E., Brioschi M., Fernandez A
doi: 10.1021/jf049605v
