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Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option
10 Taken together, these observations indicate that immunogenic proteins and peptides can be present in the intestinal lumen and thus can serve as potential candidates for intestinal absorption and immune stimulation
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