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APL Bioengineering (2021) 5(3):8995
Lysosomal LC3B conjugation was abolished by shRNA-mediated knockdown of the obligate E3-like component ATG5 but not of ATG13, which is required for canonical macroautophagy but dispensable for CASM 15 (Extended Data Fig
The idea is that injecting glutathione gives higher, more immediate systemic levels than oral or topical forms, which theoretically could affect skin pigmentation more strongly
Nature 413:118121 Lipton AJ, Johnson MA, Macdonald T, Lieberman NW, Gozal D, Gaston B (2001) S-nitrosylothiols signal ventilatory response to hypoxia
