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To characterize HCAR1 signaling pathways, a study using a cell line designed to express human HCAR1 (CHO-K1) showed activation of extracellular signal-regulated kinases (ERK1/2) via HCAR1 in response to lactate and DHBA and sensitivity to the G i protein inhibitor pertussis toxin (Li et al., 2014)

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This globular glycoprotein has been demonstrated to regulate inflammatory responses, as it is part of the innate immunity defense system and can modulate immune cell functions

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N., Chowdhury, S., Biozid, S., Faruk, Md., Mazumdar, M

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