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Some phytochemicals may stimulate phase I detoxification enzymes and also increase cellular potential for detoxification of drugs, which may cause either a decrease in sensitivity to the drug or even complete resistance

Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes

PubChem (2026) 8

Sulforaphane inhibits the generation of amyloid-beta oligomer and promotes spatial learning and memory in alzheimer's disease (PS1V97L) transgenic mice