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Thus, 29 chemicals were chosen for which there was a clear consensus about their mode of action and preferential mechanism of hepatotoxicity, classifying them accordingly into five major mechanisms groups: oxidative stress (OS), mitochondrial disruption (MI), apoptosis (APT), steatosis (ST) and cholestasis (CHOL)

The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome

Chen N, Liu Y, Greiner CD, and Holtzman JL (2000)

Recent advances in the search for novel 5-lipoxygenase inhibitors
