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Investigational Both are trial-stage compounds

Research involving reproductive-aged men demonstrated that urinary levels of phthalate monoesters and oxidative metabolites were significantly associated with increased sperm DNA damage, indicating direct genotoxic effects of these ubiquitous chemicals ( 4.1.1.3 Hormonal regulation and EED impact The fundamental role of androgens in spermatogenesis regulation provides a critical framework for understanding EED reproductive toxicity

Deletion of GIP receptor has been found to counteract high-fat diet induced weight gain in mice, suggesting a causal role of GIP in development of obesity [36]

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