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[22] [23] Baseline assessment should be considered before initiating tirzepatide in high-risk patients, including those over 65 years of age, individuals with pre-existing gastrointestinal disorders, patients on concurrent metformin or acid-suppressing medications, and those following restrictive diets

[DOI] [PubMed] [Google Scholar] 120.Swanson J, Gupta S, Lam A, Shoulson I, Lerner M, Modi N, et al

366,453,454 The relationship between these structural and functional brain changes and metabolic factors remains poorly understood, with potential mechanisms including vascular injury, oxidative stress, osmotic imbalances, and glial and neuronal damage

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