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Additionally, IR can also impair mitochondrial function by disrupting oxidative phosphorylation pathways, leading to an increase in ROS, which in turn damages sperm DNA and proteins [7, 161]

Acarbose significantly reduces body weight and abdominal obesity, decreases epicardial fat, intima-media thickness, C-reactive protein levels, and improves HDL (high-density lipoprotein) levels in patients with metabolic syndrome [148]

While these mechanistic studies are valuable, the doses and routes of administration used in many animal studies are not directly translatable to oral supplementation in humans