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These data were consistent with another study where TMAO pre-treatment for 24 h significantly reduced NO production after ATP stimulation in BAEC-1, indicating the potential involvement of TMAO in damaging the endothelial-dependent vasodilatory mechanism [57]

Its role is also being investigated for Alzheimers disease and dementia, cardiovascular and peripheral artery disease, insulin resistance and diabetes, infertility, osteoarthritis, athletic performance enhancement, and weight loss

From a label standpoint, take with food is often a safer, more practical instruction than promising immediate energy effects