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Challenges of RNA delivery The incorporation of RNA-based treatments against genetically predisposed diseases, such as polyneuropathy of hereditary transthyretin-mediated amyloidosis (Patisiran), acute hepatic porphyria (Givosiran), primary hyperoxaluria type 1 (Lumasiran) and primary hyperlipidemia (Inclisiran), seems promising (Padda et al., 2024) and can lead to potential therapeutics

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