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In contrast, disruption of a particular mitochondrial carrier protein, solute carrier family 25 member 1 ( SLC 25A1), is distinctive, as its mutation leads to an increase of a racemic mixture of both D -2HG and L -2HG, thereby exacerbating disease activity to a greater extent than other alterations

In our study, urinary levels of TGF- 1 were also increased (and subsequently reduced by alamandine co-therapy)