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Through systematic integration of the aforementioned research directions, amino acid metabolite biomarkers can advance from purely associative discoveries to validated clinical utility tools, ultimately serving individualized nutritional therapy and management of DKD patients

Blunting pulsatility by maintaining a sustained GHRH stimulus may suppress endogenous GH pulse architecture over time, which is associated with the GH-related side effects (water retention, joint stiffness, elevated fasting glucose) at higher doses

A zero-valent-iron nanoparticle (ZVI-NP) can promote ferroptosis in lung cancer cells by enhancing phosphorylation-dependent ubiquitination and Nrf2 degradation, and preferentially accumulate in tumor and lung tissues

Overexpression of the phgdh gene has been observed in colon 126 and gastric cancers 127 , and is associated with poor prognosis, higher tumor grade and larger tumor sizes in CRC 128