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In interface 2, H359 engages in hydrogen-bonding interaction with T148 and E167 of Actin

The principal risk factors for CVDs are genetic predispositions, metabolic syndrome (MetS), inadequate dietary and lifestyle habits, and physical inactivity (8)

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Inhibition of the JAK2-STAT3 pathway significantly reduces IL-1 production by astrocytes in diverse disease models (128, 129)