glutathione reductase selenium Simplified catalytic mechanism of the peroxidase: in the Proposed catalytic mechanism of glutathione
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[DOI] [PubMed] [Google Scholar] 5.Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruz R, Garcia E, Hidalgo M, Cebrin D, Heuchel R, Lhr M, Berger F, Bartenstein P, Aicher A, Heeschen C

Mutations could also lead to G6PD instability and disrupts protein folding which affects the amount of functional protein in vivo

Given the growing evidence that ferroptosis plays a crucial role in TSCI, PPARa represents an actionable target for protecting neurons from ferroptosis during the secondary phase of TSCI, potentially leading to new therapeutic strategies for TSCI
