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Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation
Therefore, the combined study of ferroptosis and Pyroptosis promotes in development of cancer therapy
Andreeff, M, Opetz, Gruner B
Bleijs M, van de Wetering M, Clevers H, Drost J (2019) Xenograft and organoid model systems in cancer research
