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Methods: A qualitative meta-synthesis using a meta-study approach was conducted

Importantly, HSPA1 can be degraded by the UPS, and CHIP blockade prevents this degradation, which is a useful tool for slowing the pace of cell death (e.g., in cardiovascular pathology) ( HSC70 has been recently shown to ensure proper interaction between S-phase kinase-associated protein 1/cullin 1/F-box protein (SCF) and constitutive photomorphogenesis 9 signalosomes (CSNs) (Zeng et al., 2025)