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At a release dose of 500 iu every 3 days, via a subcutaneous route, we would see something like this: Figure 12 Approximate average daily release of HCG at 500iu every 3.5 days, via subcutaneous administration It should be noted that this does not show the biphasic nature of HCG, where a subsequent peak will occur

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By contrast, analogue 2e was a clear outlier, with a significantly weaker score [-6.1], and was uniquely predicted as a P-gp substrate