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While direct drug interactions are unlikely based on known mechanisms, the lack of safety studies and standardized formulations means healthcare providers cannot definitively assess safety or benefit
The neurologic manifestations of vitamin B12 deficiency are not specific, and other causes of subacute to chronic neuropathy, myelopathy, or both will need consideration depending on the clinical scenario
Each works through a different mechanism, and the evidence levels are very different
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Scientific Reports (2022): 484
