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The competitive IRAP inhibitor 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity
Mentula S, Harmoinen J, Heikkil M, Westermarck E, Rautio M, Huovinen P, et al
The optimal concentration window stimulates maximum growth, while higher concentrations can trigger inhibitory feedback
a , e by two-tailed unpaired t -test
