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Identification of DHODH as a therapeutic target in small cell lung cancer

CYP24A1, a gene that provides instructions for making the enzyme 24-hydroxylase, is involved in the catabolism of both 25(OH)VD 3 and 1,25(OH) 2 D 3, thereby limiting vitamin D receptor (VDR)/1,25(OH) 2 D 3 signaling 14

Its a precursor to NAD+, a coenzyme critical for metabolic processes