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Upon binding to GHRHR, CJC-1295 without DAC triggers a sophisticated intracellular signaling cascade that begins with conformational changes in the receptor structure, leading to activation of stimulatory G-proteins (Gs) and subsequent stimulation of adenylyl cyclase activity
doi: 10.1172/JCI99751 84 GaoLGuoYBiswalMLuJYinJFangJet al
Notably, this process acts independently from autophagy and the oxidized cargo protein is degraded directly in the lysosome (Soubannier et al., 2012)
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