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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]
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The data available to date do not suggest obvious differences in efficacy among antidotes, with the exception of a slower onset of action of sodium thiosulfate (administered alone) than of the other antidotes

10.1111/jcmm.14293 77 ShenJ.WangG.ZuoJ
