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Description
Inherited Disorders of the -Glutamyl Cycle At least two genetic enzyme defects lead to the overproduction of 5-oxoproline

Additional research, including studies from our collaborative research groups, has shown that severe reactive astrocytes exhibit the increased production of H 2 O 2 through MAO-B, leading to AD pathology hallmarks such as tauopathy, cognitive decline and neuronal atrophy 57

B., Bain, S., et al

doi: 10.1016/s0896-6273(00)00085-4
