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For instance, Bahukhandi et al

Tallan A, Feng Z

A refolding reaction was considered to be finished when the derivative was below 5% of the maximum rate of change

Cerebral spinal fluid (CSF) is considered the appropriate surrogate to evaluate cerebral CoQ10 status, and in view of the low levels of CoQ10 present in this matrix, only highly sensitive analytical techniques such as HPLC-ED and tandem mass spectrometry are appropriate for this analysis [60]
