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TSC-deficient cells were found to have depleted IRS-1 mRNA, an effect that is reversed by treatment with rapamycin, which inhibits unrestrained mTORC1 activation (122, 290)

They used vitamin E (VE) as a control, and despite the fact that sperm concentration and sperm acrosin activity improved in the VE control group after treatment, there was no statistically significant difference

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