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Metabolic reprogramming in non-small cell lung cancer: unraveling therapeutic vulnerabilities and resistance mechanisms

[DOI] [PubMed] 97.Anderson PM, Bielack SS, Gorlick RG, Skubitz K, Daw NC, Herzog CE, et al

[ 1 ] Heterodimers of BACH1MAF bind to MAF recognition elements (MAREs, a unique DNA sequence of 5TGACTCGCA3) in the target gene promoters, thereby suppressing or initiating genes transcription

Thus, cell-intrinsic programs drive immune cells and cancer cells to preferentially consume glucose and glutamine, respectively [66].Similarly, there are cell-intrinsic programs in stromal cells in the TME, which regulate the local sources of glutamine to compensate for the glutamine depletion in the TME
