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When both cultivars were exposed to salt stress, Pokkali showed higher GSH/GSSG ratio and ascorbate (AsA)/dehydroascorbate (DHA) ratio, together with higher activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), and GPX, when compared to IR64

GSH functions as a signaling molecule which activates the breast cancer stem cell phenotype through copper chelation that leads to an inhibition of mitogen-activated protein kinase kinase (MEK) activity, leading to inactivation of MEK1-ERK signaling, FoxO3 dephosphorylation, and nuclear translocation ultimately leading to enrichment of breast cancer stem cells [158] High ROS production in cancer cells requires high activity of cellular antioxidant systems making cancer cells hypersensitive to exogenous agents that damage their antioxidant capability