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Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals
In this review, we have discussed the recent progress in GSH biosynthesis, metabolism and its role in abiotic stress tolerance
[DOI] [PMC free article] [PubMed] 194.Baselga J, Morales S, Awada A, Blum J, Tan A, Ewertz M, et al
(Figure 4)
