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Circulation 108: 16401645 [DOI] [PubMed] [Google Scholar] 87
GSK-3 phosporylates Nrf2 which leads to its ubiquitination and subsequent degradation, thus when GSK-3 is inactived Nrf2 is upregulated and leads to higher expression of antioxidative enzymes [99]
10.5812/asjsm.24898 122 ZiogasV.TanouG.MolassiotisA.DiamantidisG.VasilakakisM
It also serves as a significant tumor suppressor in various cancers
