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Of note, many investigational agents have previously been found to be ineffective to slow ALS progression, highlighting the potential need to target multiple pathophysiologic mechanisms simultaneously [205]
doi: 10.1177/0883073813498821
This technique has provided key insight into the molecular mechanisms of activation of lipid signalling enzymes downstream of GPCRs (Dbouk et al., 2012
doi: 10.1067/moe.2000.106340
