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Breast carcinoma cell lines exhibit more aggressive, migratory behavior when stimulated with IGF-1 or when overexpressing IGF-1R in vitro [108,112], while knockdown of IGF-1R expression impairs colony formation and invasion [108]
All these classes of pharmaceuticals carry specific side effects and require professional long-term monitoring and management of adverse effects [18, 344, 541, 576]
Etienne-Manneville S 2018 Cytoplasmic intermediate filaments in cell biology