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Tirzepatide is a dual agonist (GIP + GLP-1)
In particular, proximal tubular epithelial cells express CYP27B1, which converts circulating 25-hydroxyvitamin D [25(OH)D] into its biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D]

10.1093/cercor/10.10.927 [DOI] [PubMed] [Google Scholar] Thanseem I., Nakamura K., Miyachi T., Toyota T., Yamada S., Tsujii M., et al
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