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GABA is produced by the enzyme glutamic acid decarboxylase (GAD) that catalyzes the decarboxylation of Glu, and the production of GABA produces an inhibitory effect on the excitatory properties of GLU in order to maintain the neural excitability/inhibition balance [20]

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Inhibiting histone deacetylase as a means to reverse resistance to angiogenesis inhibitors: phase I study of abexinostat plus pazopanib in advanced solid tumor malignancies