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Li YQ, Zhang ZX, Xu YJ, Ni W, Chen SX, Yang Z, Ma D
DOI: 10.1002/adbi.20230025 Feature image credit: Kenny Eliason on Unsplash
Paradoxically, while iron toxicity in PD is linked to dysfunctional iron metabolism, intragastric delivery of iron carbonyl boosts the biosynthesis of iron-sulfur clusters and elevates aconitase 1 activity, which is crucial for mitochondrial function and iron homeostasis, thereby preventing ferroptosis in vivo (188)
Thus, our data proves the mitoprotective properties of exogenous glutathione pretreatment
