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As CrAT is present in the peroxisomes, peroxisomal CrAT converts a substantial amount of acetyl-CoA to acetylcarnitine [149]
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Further studies are needed to elucidate the role of LAIR-1 in other cancer models and its role in modulating anti-tumor immunity
Another HLA risk allele identified in genome-wide association studies is the rs2476601 variant in the PTPN22 gene, which is associated with an increased risk of DILI from multiple drugs
Movafagh S, Crook S, Vo K
