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Through establishing an interleukin (IL)-1-stimulated chondrocytes, it was found that L-theanine could inhibit the nuclear factor kappa B (NF-B) pathway, thereby reducing the expression of proinflammatory factors, including cyclooxygenase-2 (COX-2), prostaglandin E2, inducible nitric oxide synthase, as well as NO, and protect the degradation of extracellular matrix (29)
For an adult on a 2,000-calorie diet, that would equate to about 5 grams of fish oil per day
Activation of the TLR/NLRP3/NF-B pathway has been reported to induce inflammation in rat models [123, 143, 144]
FEMS Yeast Res 2005;5:121528
