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Using the zebrafish model, the researchers observed that Me-Cbl treatment proved to be the most effective for improving the growth parameters in the cblC zebrafish, despite no significant alterations in the measured metabolites

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In view of these mechanisms, combination therapy strategies can overcome drug resistance through multitarget synergy, regulating the TME, overcoming redox homeostasis, improving drug efficacy, and effectively reversing drug resistance

Consequently, finding ways to overcome the limited therapeutic effect imposed by the BBB has become a central goal in advancing delivery systems targeted to the brain