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Side effects: GLP-1 medications are frequently associated with nausea, constipation, gastroparesis, and, in some patients, significant muscle mass loss alongside fat loss

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs