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NO influences CRC by modulating the tumor microenvironment, mechanostress responses during metastasis, and signaling through extracellular vesicles (EVs), thereby aiding immune evasion

[] Dysregulated bile acid metabolism has been implicated in metabolic syndrome, insulin resistance, and cardiovascular diseases

doi: 10.1530/eje.0.1430197 36 Ruiz-RiolMBarnils MdelPColobran OriolRPlaASBorrs SerresFELucas-MartinAet al

In this study, the intestinal microenvironment was recapitulated by applying defined mechanical deformations and fluid hydrodynamics, exploiting a coculture with a host microbiome while allowing the real-time monitoring of cell morphology and cell-cell interactions, in a manner not possible with a standard organoid culture